The Benefits of Testosterone Therapy


A number of benefits of testosterone therapy have been demonstrated, including effects on mood, energy levels, and libido. Long-term follow-up of testosterone therapy in hypogonadal males and a control group indicates that self-assessment of libido was significantly higher (p<0.0001) in the testosterone-treated group. Testosterone therapy has also been shown to enhance libido and the frequency of sexual acts and sleep-related erections. Transdermal testosterone therapy, in particular, has been linked to positive effects on fatigue, mood, and sexual function, as well as significant increases in sexual activity. More specifically, testosterone therapy has been shown to improve positive mood parameters, such as feelings of wellness and friendliness, while reducing negative mood parameters, such as anger, nervousness, and irritability. Testosterone therapy is an effective treatment for some depressive symptoms in hypogonadal men and may effectively augment treatment in selective serotonin reuptake inhibitor (SSRI)-refractory major depression. Relative to eugonadal men, hypogonadal men in one study were impaired in their verbal fluency and showed improvement in verbal fluency following testosterone therapy.

Testosterone therapy is also associated with potentially positive changes in body composition. In hypogonadal men, testosterone therapy has demonstrated a number of effects, including an increase in lean body mass and decrease in body fat, an increase in weight, and increases in muscle size. Parenteral testosterone therapy in hypogonadal men resulted in improved strength and increased hemoglobin compared to controls. In another study by Urban and colleagues,28 testosterone administration also increased skeletal muscle protein synthesis and strength in elderly men. Testosterone therapy with transdermal testosterone delivery systems in HIV-infected men with low testosterone levels has been associated with statistically significant gains in lean body mass (p=0.02), increased red cell counts, and improvements in emotional distress. Transdermal testosterone has also been administered to HIV-positive women, yielding positive trends in weight gain and quality of life.

Improvements in bone density have also been shown with testosterone therapy. Increases in spinal bone density have been realized in hypogonadal men, with most treated men maintaining bone density above the fracture threshold. Testosterone therapy in hypogonadal men improves both trabecular and cortical bone mineral density of the spine, independent of age and type of hypogonadism. In addition, a significant increase in paraspinal muscle area has been observed, emphasizing the clinical benefit of adequate testosterone therapy for the physical fitness of hypogonadal men.





• Increased male sex drive

• Improve male sexual performance

• Enhance mood in men

• Reduce depression in men

• Increased energy and vitality

• Increase male bone density

• Improve male fertility

• Increases production of sperm cells

• Increased strength and endurance

• Regulate distribution of body fat

• Increase body hair growth

• Reduce risk of heart disease

• Develops lean muscle mass